Dr. Andrew Huberman on Alpha GPC: What You Need to Know

Dr. Andrew Huberman on Alpha GPC: What You Need to Know

Nootropics and brain health supplements are becoming more popular as people look for ways to enhance their cognitive function and overall mental well-being. This growing interest is driven by the increasing demands of modern life, where stress and mental fatigue are common issues. More individuals are seeking natural supplements to boost their brain power and maintain cognitive health.

Dr. Andrew Huberman is a renowned neuroscientist and professor at Stanford University. He is well-known for his research on human brain function, neuroplasticity, and the effects of various substances on cognitive performance. Dr. Andrew Huberman’s work has shed light on how certain supplementation in humans, including Alpha GPC, can improve brain health and enhance cognitive abilities.

This article will focus on Alpha GPC, a popular nootropic known for its cognitive benefits. We will explore its functions, benefits, and what Dr. Andrew Huberman has to say about its use and the implications for health. By the end of this article, you will have a comprehensive understanding of supporting brain health and the role of Alpha GPC with Huberman Lab’s expert insights.

A person running on a trail next to trees

What Is Alpha GPC?

Alpha GPC (L-Alpha Glycerylphosphorylcholine) is a natural choline compound found in the brain. It is derived from soy or sunflower lecithin and is highly bioavailable, meaning it easily crosses the blood-brain barrier to deliver choline directly to the brain. This compound has been studied for its potential to enhance cognitive function and support brain health​.

Alpha GPC can be found in small amounts in foods such as organ meats, dairy, and wheat germ. However, most people consume it through dietary supplements. It is available in various forms, including capsules, powders, and liquids, making it convenient for different preferences and needs​.

Alpha GPC plays a crucial role in the production of acetylcholine, a neurotransmitter that is essential for memory, learning, and mental clarity. When Alpha GPC is ingested, it is converted into its bioavailable form, acetylcholine in the brain, boosting brain choline levels. This neurotransmitter plays a critical role in supporting cognitive functions and is vital for communication between nerve cells and brain tissues​.

By increasing acetylcholine levels, Alpha GPC enhances cognitive abilities such as memory retention, learning, and mental clarity. It also plays a role in cell membrane health and may promote the formation of new brain cells. These effects make Alpha GPC a valuable supplement for improving cognitive function and maintaining overall brain health​.

Alpha GPC is recognized for its potential neuroprotective properties, making it a popular choice for those looking to enhance their cognitive performance and support brain health. When it comes to the benefits of Alpha GPC, Huberman has boosted its popularity in the nootropic community.

Benefits of Alpha GPC

Cognitive Enhancement 

Alpha GPC is known for its significant cognitive benefits. Studies show that it can improve memory and learning abilities. This is due to its critical role in increasing acetylcholine levels, a neurotransmitter essential for cognitive functions. Enhanced acetylcholine levels help with memory retention and learning processes, making Alpha GPC a valuable supplement for students and professionals. Additionally, it has the potential to delay cognitive decline, which is beneficial for older adults at risk of conditions like Alzheimer’s disease.

Physical Performance 

Alpha GPC is not just for the brain; it also benefits athletic performance. For gym-goers and bodybuilders, it can increase strength and power output. Research indicates that taking Alpha GPC before workouts can significantly enhance lower body strength and overall athletic performance. This is partly due to its ability to stimulate the production of human growth hormone (HGH), which supports muscle growth, tissue health, bone health, blood flow, and recovery.

Mood and Mental Health 

Alpha GPC also plays a key role in improving mood, reducing anxiety, and improving sleep quality. By boosting acetylcholine levels, it enhances mental clarity and focus. Some studies suggest that Alpha GPC can modulate the stress response, leading to better mood and sleep quality, and reduced symptoms of anxiety. These effects make it a useful supplement for those looking to enhance their mental well-being and cognitive performance under stress.

Overall, Alpha GPC is a versatile supplement that supports cognitive functions, physical performance, and mental health. Its benefits are well-documented, making it a popular choice among those seeking to improve their brain and body performance.

A man exercising on a mat

Insights on Alpha GPC by Huberman

Dr. Andrew Huberman, a well-known neuroscientist, has conducted extensive research on Alpha GPC. He highlights its benefits for both cognitive function and physical performance. According to Dr. Andrew Huberman, Alpha GPC enhances acetylcholine production in the brain, which improves focus, memory, and learning. He mentions that studies show Alpha GPC can increase power output by about 14%, making it beneficial for both mental and physical activities​.

Dr. Huberman also points out the neuroprotective properties of Alpha GPC, which can help mitigate cognitive decline, particularly in older adults. This supplement supports brain cell health and neuroplasticity, making it a valuable tool for maintaining cognitive function over time. Additionally, Huberman notes that Alpha GPC can enhance the brain’s ability to adapt and grow, a process known as neuroplasticity, which is crucial for learning new skills and helping brain tissue recover from brain injuries.

By following these guidelines, individuals can safely incorporate Alpha GPC, per Huberman, into their routines and experience significant improvements in both mental clarity and athletic performance.

Clinical Doses and Recommendations 

Dr. Huberman emphasizes the importance of taking clinical doses to maximize the benefits of Alpha GPC. He typically recommends a dosage of 300 to 600 milligrams per day for general cognitive enhancement and athletic performance. For those aiming to combat cognitive decline, higher doses of up to 1200 milligrams per day may be used under medical supervision. He also advises pairing Alpha GPC with other supplements, such as caffeine or Huperzine-A, or magnesium L-threonate to amplify its cognitive effects.

Dr. Huberman emphasizes the importance of using clinical doses to ensure effectiveness. He also cautions about the potential long-term risks associated with chronic high-dose usage, such as an increased risk of stroke. To mitigate this risk, he suggests taking garlic supplements to counteract the potential increase in TMAO levels, a marker associated with cardiovascular health risks​.

Revive MD's Alpha GPC Supplement

A bottle of Revive’s Brain+

ReviveMD's Brain+ supplement is a natural product designed to support cognitive function, memory, and focus. It includes Alpha GPC, a choline-containing supplement known to boost brain choline levels, which helps enhance cognition and protect nerve cells. Brain+ is vegan-friendly, gluten-free, and soy-free. It contains no fillers or synthetic ingredients, ensuring a clean, natural product for those looking to support their cognitive health.

Third-Party Testing and Purity

ReviveMD emphasizes the importance of third-party purity testing to ensure the quality and safety of its products. This commitment to transparency means that each batch of Brain+ is tested for purity and potency, ensuring customers receive a product that meets high standards. Third-party testing is crucial for verifying that the supplement is free from contaminants and accurately labeled, which builds trust and confidence in the brand.

Multi-Ingredient Formulation 

Brain+ is designed with a multi-ingredient approach to support various aspects of brain health. Alongside Alpha GPC, it includes choline and lithium, which are known to enhance neurotransmitter function and protect neurons from stress and toxins. This combination helps improve focus, memory, and overall cognitive function. The multi-ingredient formulation ensures that users receive a comprehensive brain health supplement that addresses multiple pathways and mechanisms for optimal cognitive support.

ReviveMD's Brain+ supplement leverages the benefits of Alpha GPC and other brain-supporting ingredients to offer a well-rounded product for cognitive enhancement. The emphasis on vegan, non-GMO, and gluten-free ingredients, coupled with rigorous third-party testing, highlights ReviveMD's commitment to quality and transparency. The insights provided on the benefits and proper usage of Alpha GPC by Huberman further validate the effectiveness of Alpha GPC for those seeking cognitive and physical performance enhancements​.

How to Incorporate Alpha GPC into Your Routine

To get the most out of Alpha GPC, it’s important to take it correctly. For optimal results, take Alpha GPC about 30-45 minutes before any cognitive tasks or workouts. This timing helps ensure that the supplement enhances your focus and athletic performance when you need it most. The typical dosage ranges from 300 to 600 milligrams per day. Start with the lower end of the dosage to see how your body responds and adjust if necessary.

Pairing Alpha GPC with other supplements can also be beneficial. It works well with caffeine for an added boost in focus without the jitters. Combining Alpha GPC with other nootropics, like with Brain+, can enhance its cognitive benefits. This combination helps improve memory, focus, and overall brain function​.

Potential Side Effects and Safety 

Alpha GPC is generally considered safe when taken within the recommended dosage range. However, some people may experience side effects such as headaches, dizziness, heartburn, or nausea. These side effects are usually mild and temporary. It’s always a good idea to start with a lower dose to see how your body reacts​.

Certain individuals should avoid taking Alpha GPC or consult with a healthcare professional before starting. This includes people with pre-existing health conditions, those taking medications that affect the nervous system, and pregnant or nursing women. Additionally, long-term use of high doses may carry a risk of increasing TMAO levels, which is associated with cardiovascular health risks. To mitigate this, Dr. Andrew Huberman suggests taking garlic supplements alongside Alpha GPC to help manage TMAO levels​.

In Short:

Alpha GPC offers numerous benefits for both cognitive and physical performance. Dr. Andrew Huberman's research highlights its ability to enhance focus, memory, and learning by boosting acetylcholine levels in the brain. He also notes its benefits for physical performance, including increased strength and power output. Using clinical doses of Alpha GPC, typically 300-600 milligrams per day, is crucial for achieving the most noticeable difference safely and effectively​.

Consider adding Alpha GPC to your supplement routine to improve your cognitive function and physical performance. ReviveMD's Alpha GPC product, included in their Brain+ supplement, provides a high-quality, vegan-friendly, non-GMO, and gluten-free option. It also undergoes rigorous third-party testing to ensure purity and effectiveness. Incorporating this supplement can help you achieve better focus, memory, and overall brain health. Try ReviveMD’s Alpha GPC to experience these benefits firsthand​.


The information being presented in this blog is intended to be used as educational or resource information only. It is not intended to be a substitute for medical advice from your healthcare provider. This content should not be used for the diagnosis or treatment of any medical condition. If you have any questions or concerns about your health, please contact your healthcare provider. You should call 911 for all medical emergencies. Revive MD is not liable for any advice or information provided on this blog, which advice or information is provided on an “as-is” basis, and assumes no liability for diagnosis, treatment, decisions, or actions made in reliance upon any advice or information contained on this blog. No warranties, express or implied, are made on the information that is provided.

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